The present study was conducted to evaluate and compare four different balanced anaesthetic protocols in clinical cases of dogs undergoing various surgical procedures. In subgroup X1 and X2, glycopyrrolate was administerd followed by xylazine and pentazocine at different doses. In subgroup D1 and D2 diazepam and fentanyl citrate were administered intravenously after 15 minutes of glycopyrrolate administration. After 15 minutes of preanesthetic administration in all groups anaesthesia was induced with propofol was and maintained with isoflurane. The jaw tone was abolished earlier in subgroup X1 in comparison to other subgroups. Abolition of pedal, palpebral, corneal reflexes happened earlier in D2 subgroup in comparison to X1, X2 and D1. Induction dose of propofol was lower in xylazine group than the diazepam group viz. 3.65 ± 0.60 mg/kg in subgroup X1, 4.00 ± 0.30 in subgroup X2 and 6.08±2.03 in subgroup D1, 4.53±0.48 in subgroup D2. Glycopyrrolate caused tachycardia in all subgroup. Alpha2-agonists did not cause bradycardia and diazepam did not alter heart rate and respiratory rate, whereas propofol caused tachycardia and depression in respiratory rate and SPO. Mean arterial pressure (MAP) increased after the administration of glycopyrrolate, xylazine and pentazocine in subgroup X1 while it slightly decreased in rest of the subgroups. It was concluded that Preanaesthetic combination of glycopyrrolate (0.005 mg/kg)-xylazine (0.5 mg/kg)-pentazocine (2 mg/kg) was found best among four combinations.

Highlights

• An intramuscular anesthetic protocol containing glycopyrrolate (0.005 mg/kg), xylazine (0.5 mg/kg), and pentazocine (2 mg/kg) is recommended.
• An intravenous preanaesthetic protocol using glycopyrrolate (0.005 mg/kg), diazepam (1 mg/kg), and fentanyl (5 µg/kg) is recommended for calm and cooperative animals.